Critical care nurses are more liable for occurrence of burnout, stress and inappropriate use of stress coping mechanisms. Burnout is caused by the negative effects of job stress. Because of burnout nurses may become less productive, absent due to illness, as well as the fluctuation of staff increases. So, A quasi-experimental research design with one group pre/posttest approach was used to assess the effect of psychological educational program on Stress Coping Mechanisms and Burnout syndrome among Critical care Nurses. Setting: General, trauma, pediatric, internal medicine and open heart surgery intensive care units at Sohag University Hospital. Sample: A convenient sample of all nurses working in the selected setting and who are on the actual work force during the study time. Tools: Online questionnaire overs three tools as following, Tool Ι: The Maslach Burnout Inventory questionnaire, Tool II: The Perceived Stress Scale-10 and Tool II: The Brief COPE Inventory. Results: shows statistically significant improvements in parameters for Maslach Burnout Inventory as Mean±SD for Emotional Exhaustion was (32.29±11.36 pre-program versus 23.69±14.72 post-program), Depersonalization (12.73±6.19 pre-program versus 10.61±6.51 post-program) and Personal accomplishment (37.35±9.53pre-program versus 43.37±5.48post-program). Conclusion: application of psychological program has positive effect on reduce level of burnout, stress among critical care nurses. Recommendations: Training programs about burnout syndrome and Stress management techniques should be held periodically for critical care nurses.