Background: Low literacy patients need new methods to improve their awareness and enhance self- efficacy regarding problems related to the colostomy care. Aim: To evaluate effectiveness of video-discharge instructions about colostomy self- care on awareness and self-efficacy of low-literacy patients. Research design: Quasi-experimental study design (pre–post test). Setting: The study was carried out in the General Surgical Department and Outpatient Clinic at Assiut University Hospital Subjects: Purposive thirty low-literacy patients with colostomy. Tools: (I) Patients' awareness questionnaire which included demographic and medical data of the patients and Pre – post stoma- related awareness and (II): Stoma self - Efficacy Scale. Result: Majority of the studied patients were males their ages more than 40 years old and not work (76.7%, 66.6% and 66.7% respectively). Half (50%) of them diagnosed with cancer colon. A significant statistically difference was found regarding total awareness, and self- efficacy scores of the studied patients between pre and post implementation of the videodischarge instructions with a positive correlation among them. Conclusion: That implementation of video-discharge instructions about colostomy self-care had a positive effect on awareness and self-efficacy of low literacy patient. Recommendation: For managing every aspects of stoma care should be a top priority, preferably before leaving the hospital. For low literacy patients who should be included in hospital programs provided by ostomy care team for improving their awareness, self-efficacy, prevention and treatment of their complications.