Background: Mindfulness is the practice of purposely bringing one's attention to the present moment without evaluation, a skill one develops through meditation or other training. Subjects and Method: The present study aims to examine the effect of a brief mindfulness-based intervention on emotional regulation and levels of mindfulness among patients with a schizophrenia spectrum disorder. A quasi-experimental study design was used. Convenient sampling was applied to recruit fifty schizophrenic patients from the psychiatric health and addiction treatment hospital in Port Said City. The data were collected through two tools including the mindfulness scale and the difficulties in emotion regulation scale, in addition to the personal and clinical datasheet. The sample was assessed before the training program and immediately after finishing the program. Results: The study revealed that there was a statistically significant negative correlation between patients' levels of mindfulness and difficulties in emotion regulation. A significant improvement in the high level of mindfulness in the post-program phase. Conclusion: The current study illustrated that the best predictors for mindfulness among the studied patients are educational level, marital status, family income, and the beginning of the disease. Recommendation: Mindfulness-based intervention program for schizophrenia spectrum patients' care is recommended as a non-invasive, non-pharmacological, inexpensive, and cost-effective method without complications.