Depression is a common illness worldwide and its burden is on the rise. It causes feelings of sadness and/or a loss of interest in activities once enjoyed and can lead to a variety of emotional and physical problems and can decrease a person's ability to function at work and home. The study aimed to assess the psychosocial functioning and quality of life among depressed patients. Design: A descriptive research design was used. Subjects and method: The convenient studied sample includes 70 patients with depressive disorders. Tools: Included structured interview questionnaire (Demographic and clinical characteristics), Beck depression inventory scale (BDI), Quality of Life Scale (QoL), Impairment function scale (SDS). Results: Depressed patients have highly impaired in their quality of life and poor functioning. Most depressed patients, have eht highest impairment in family life, followed by social life, and the last impairment was at work and school impairment. Conclusion: Depressed patients have a high level of social, physical, and cognitive functional impairment. Recommendation: Psychosocial intervention should be delivered to hospitalized depressed patients as an important way for improving their social functioning.