Asthma is a serious global health problem and there is still lack of awareness regarding Buteyko Breathing Technique (BBT) and Pranayama Breathing Technique (PBT) to achieve more control over it. Aim: To compare between the effect of Buteyko and Pranayama Breathing Techniques on children with asthma. Setting: This study was conducted in in chest ward and outpatient clinic at Assiut university children hospital. Method: Quasiexperimental design was utilized in this study on simple random sample of (90 children) through pre and post program implementation. Tools: Three tools were utilized; the first tool, patient assessment questionnaire, the second tool used to assess bronchial asthma symptoms‟ severity and the third tool used to assess level of asthma control. Result: Showed that all asthma severity and asthma control items were a highly significant improved after applied BBT & PBT at p-value <0.001 but BBT was slightly better. Conclusion: This study support the effectiveness of BBT & PBT over the standard treatment in asthmatic children. There was a statistically significant improvement of daily Asthma Control, Asthma severity symptoms, over pre applied it. Recommendations: The researchers recommend that BBT & PBT be added as a possible medical and nursing intervention in managing asthmatic children.