Cesarean section is accompanied by persistent post-operative pain. Inadequately managed postoperative pain is prevalent worldwide which adversely affects women's psychological status and outcomes that are associated with an increase of women's stress, anxiety and depression. Aim: To evaluate the effect of a nursing intervention program for women post-cesarean section regarding self-care theirs on psychological status (i.e., anxiety and/or depressive symptoms) and postoperative pain. Subjects and Method: Design: Quasi-experimental research design pre-post-test was used. Settings: The study was applied in the obstetrics and gynecology department in Beni-Suef University Hospital. Sample: A purposive sample was used to choose a sample of 100 post-cesarean women and recruited from the selected settings. Tools: (1) A structured interviewing questionnaire, (2) a Depression, Anxiety, and Stress Scale (DASS), and (3) Numerical Pain Rating Scale (NPRS). Results: knowledge level has been improved with statistical significance after nursing intervention program implementation as well as self-care practices after cesarean section post-intervention in comparison to pre-intervention program implementation. A statistically significant difference was detected in the pain level among women after nursing intervention program implementation. A statistically significant relationship was found between knowledge and self-care practices scores throughout the intervention phases. there were highly statistically significant improvements were observed in women's total scores of depression, anxiety, and stress scores regarding the caesarian section at (P<0.001). Conclusion: The nursing intervention program implemented for cesarean section women was effective in improving women's psychological status and reducing postoperative pain. Recommendation: A nursing intervention program should be integrated into the care among women submitted to cesarean section.