Creating an ethical climate in organizations results in better psychological well-being, the performance of employees, job satisfaction, and organizational productivity. The study aimed to examine the nurse's perceived ethical climate, psychological well-being, and job satisfaction following the Covid- 19 outbreak. Design: Crosssectional study design. Sample and Setting: A convenient sample was used in the current study, which included all staff nurses (199 nurses) who work in isolation hospitals (Minia psychiatric mental health hospital (59 nurses) and Minia health insurance hospital (140 nurses). Tools: three tools were utilization, tool (1) Hospital Ethical Climate questionnaire, tool (2): psychological well-being scale, and tool (3): job satisfaction questionnaire. Results: the majority of nurses have a satisfactory ethical climate. More than half of the study sample has moderate job satisfaction and positive correlation between hospital ethical climate and psychological well-being and job satisfaction. Conclusion: moderate positive correlation between hospital ethical climate with psychological wellbeing and job satisfaction. Recommendations: Further studies are needed to clear indicators such as personal and clinical data that influence hospital ethical climate, psychological well-being, and job satisfaction among nurses.