Background: Postoperative knee swelling and pain are common after total knee arthroplasty. The use of a compression therapy and leg position would reduce knee swelling and improve pain. Aim: To evaluate the synergistic effect of compression therapy and leg position on patients post total knee arthroplasty swelling, pain and range of motion. Setting: Orthopedic department at Assiut university hospital. Subjects: A convenience of 150 adult patients who randomly and equally divided into three groups (50 each) Patients encountered in the study had the following criteria: adult patients from both gender and on the day of operation. While the patient who were uncooperative or use compression therapy were excluded from the study sample. Tools: Patients' demographic and medical data sheet, swelling measuring scale, analogue pain scale, range of motion scale were utilized. Results: No statistically significant difference was found between studied groups regarding their demographic and medical data. Also, there was a significant decrease of post-operative knee swelling and improvement in range of motion degrees mainly among compression and leg position group when compared with other groups either compression therapy or leg position (P. 0.002 and 0.021 respectively). Conclusion:  significant difference existed between all studied groups regarding swelling and range of motion degrees but no statistical significance regarding pain mean scores post total knee arthroplasty.Recommendation: Using compression therapy with leg exercise indorsed for total knee replacement arthroplasty patients to minimize swelling improve range of motion and prevent complications post- operatively.