Background: Head nurses play a major role in managing patient safety, which is considered a critical component of quality health care. Aim: To assess the effect of applying a training program about reducing the risk of patient fall on patient's safety culture at Rajhy Liver Hospital, Assiut University. Subject and Method: A quasi-experimental design used to conduct this study. The study subject included one nursing director and (n=28) head nurses, their assistances, and charge nurses from different health care units. The data collection tool included three tools: The personal characteristics questionnaire, Head nurses management regarding patient's safety questionnaire, and Hospital survey on patient's safety culture questionnaire. Results: there was a highly statistically significant difference with a strong positive correlation impact between head nurses' management toward reducing the risk of patient fall using the PDCA model and patient's safety culture. Conclusion: The implementation of the training program is successful and effective in improving head nurses' management toward reducing the risk of patient fall using the PDCA model after implementing the training program. Recommendations: Developing a policy to conduct in-service training program and development activities related to reducing the risk of patient fall at the health care setting.