Background: Sacrococcygeal pilonidal sinus disease (SPSD) is disorder mainly observance in the sacrococcygeal region, especially in young and middle-aged males. Aim of the study: evaluate effect of phenolisation dressing technique on healing rate and daily living activity among patient with sacrococcygeal pilonidal sinus disease. Methods: quasi-experimental study was conduct in general surgery department and outpatient clinic at Qena University Hospital. A coincident sample of 60 adult patients assigned clinically into two equal comparable group study and control. The study tools; Tool 1: Patient interview assessment questionnaire. Tool 2: Pre/post healing progression rate scale. Tool 3: pilonidal disease daily living activity questionnaire. Results: statistical significant difference between studied group in wound healing parameter include exudates color, amount, odor, pain and surrounding tissues post intervention with p < 0.05. Also statistical significant difference related daily living activity behaviors between studied group with p < 0.05. Conclusion: phenol dressing technique accelerates wound healing without any side effect it is safe, inexpensive to treat sacrococcygeal pilonidal sinus. Recommendation: additional successful clinical evidence is required to establish phenol dressing technique as if the generality effective alternative intervention for treating SPSD.