Background: Managers create many decisions by diverse styles. The style of decision-making is the educated continual response design shown by the manager when he needs to create a decision. Aims: To determine decision making styles of nursing managers at Assiut university hospitals. Research design: A descriptive design was used. Setting: This study was conducted at Assiut university hospitals and south Egypt cancer institute. Subject: The study subject consisted of (245) nursing managers. Tools: Two tools were used; socio demographic data and general decision making styles questionnaire. Results: Rational decision making style has had the highest mean score (20.95±2.03, 83.8%) in all selected hospitals, and the most dominant style among the three managerial levels. While the high mean score was for Rajhi liver hospital regarding rational style (21.78±1.68). There were highly statistically significant differences between different selected hospitals regarding to intuitive and spontaneous styles (<0.001**, 0.007**) respectively. With the highest mean scores for the both styles related to south Egypt cancer institute. Conclusion: The rational style is the most dominant styles and has the highest mean score at the top management and in Rajhy liver hospital. Recommendation: Provide nurse managers with training programs about decision making styles, to enhance their experience.