Back ground: Radiation dermatitis is one of the most common side effects for the majority of breast cancer patients receiving external beam radiation therapy. Aim: To evaluate the effect of education program to promote skin integrity and reduce pain for patients receiving external beam radiotherapy. Subjects and Methods: Quasi experimental research design. Setting: Oncology department and radiotherapy outpatient clinic at Sohag University Hospital. Sample: Non-probability purposeful sample of (80) female patients (40 cases and 40 control) that has breast cancer and will receive external beam radiotherapy. Tools: Tool (I): Part (1): Patients'' personal data, Part (2): Patient’s medical history, Tool (II): Educational program to promote skin integrity before and after receiving radiation therapy. Tool (III): Part (I): Radiation Therapy Oncology Group assessment tool and Part (2): Patientreported symptoms post radiotherapy tool. Results: Highly statistical significance difference between study and control group as regarding to Radiation Therapy Oncology Group, patient-reported symptoms after treatment