Problem-based learning is students – centered pedagogy in which students learn about a topic through the experience of solving an open – ended problem found in a stimulus material. Aim: Apply Problem Based Learning Model on Secondary Technical Nursing School. Design: quasi-experimental study design. Study subject: It included all 3rd year of nursing students. Setting: It conducted at the Sahel Seleem Nursing School. Study tools: included four tools: (I) Socio-demographic data, (II) problem-based learning questionnaire, (III) self-assessment questionnaire and (IV) peer assessment questionnaire. Results: There was a high main score in skills ''knowledge base, problem solving skills, clinical reasoning, collaborative work, self-directed learning and attitude and professional skills'' of the studied nursing students after applying of Problem Based Learning Model than pre applying it; also, there were improvement in self- assessment and peer assessment. Conclusion: By using PBLM, there was an improvement of the students' skills in self-directed learning, clinical reasoning, problem solving, knowledge base, attitude and professional skills and collaborative work skills. Following the use of the problembased learning approach, self- and peer-assessment were also established. Recommendation: Develop an educational plan by those who develop the curriculum to implement problem-based learning model to students in nursing schools in Egypt.