Background: Nephrotic Syndrome is one of the prolonged illnesses of childhood that has a major link with behavioral problems. Aim: To assess effect of nephrotic syndrome on the psychosocial aspects of school age children in Assiut City. Research design: Descriptive research design. Sample: 200 children. Tools: Two tools; Tool (1):  Children personal and clinical data. Tool (2): Included child behavior checklist; parent form. Results:  The study revealed that 52%, 39% and 9% of the studied children had abnormal, normal and borderline problem score respectively. There were statistically significant differences between the total competence score with children age, educational level and duration of illness p-values=0.001,0.038and 0.038 respectively. Also, there were positive correlations between total score of problem and total score of competence scales among the studied children. Conclusion: This study pointed out that children who were suffering from nephrotic syndrome are at increased risk of developing psychological difficulties. Recommendations: Community, psychiatric and pediatric health nurses should be trained on how to deal with children suffering from nephrotic syndrome and to detect cases that needs preventive interventions.