Background: The Swiss cheese model (SCM) has proven extremely effective and powerful in learning and planning. Aim of the study: evaluate the effect of the Modified Swiss cheese model on patient safety, patient safety culture, and medication errors among nursing students. Methodology: A quasi-experimental research design was used in this study. Setting: The study was conducted at the Faculty of Nursing, Port Said University, Al-Salam & Al-Nasr hospitals, Port Said. Subjects: Convenient sample, which included all students in the final academic year. Tools: Three tools were used for data collection included Tool I, Patient Safety in Nursing Education Questionnaire. Tool II, Healthcare Professionals Patient Safety Assessment Curriculum Survey. Tool III, The patient safety culture assessment. Results: There is a positive effect of the modified Swiss cheese model on the knowledge, skills, and attitude domains competencies related to patient's safety during post-test compared to the pre-test, with a p-value of 0.000. Conclusions: Implementation of modified Swiss cheese model showed positive levels of students' competencies domains (knowledge, skills, and attitude) toward patient safety. Recommendation: A need to revise the nursing curriculum and to use various teaching methods to deliver patient safety education more comprehensively and effectively.