Background: Polycystic ovary syndrome is an intricate endocrine disorder that affects 6-10% of females of reproductive age. Aim: To assess the level of awareness of nursing student regarding Polycystic ovary syndrome in King Abdulaziz University. Methods: In this study, A total of 158 convenience samples out of 408 were collected from female nursing students at KAU through three weeks in March,2020. It used a descriptive quantitative design by it utilized an adaptive questionnaire from (Aqeel Nasim). Results: The results inferred that (38.6%) of participants were in the age group range from 19 to less than 21 years. Regarding educational level of their mothers (51.2%) of them have a university degree or more. Most of the participants (82.9%) had an overall moderate knowledge about PCOS. Conclusion: According to the findings of this study and the data analysis was concluded that, most of the students were aware about PCOS" but do not have enough knowledge. More than three quarters of them had moderate knowledge on PCOS. Recommendation: Conducting an educational program for young girls in different setting to increase levels of awareness concerning polycystic ovarian syndrome educational program.