Background: The 21^st century hospitals that are closed and accusatory in which nurses feel unvalued, and not esteemed are considered as toxic workplaces which sequentially will remain nurses more silent about variety of issues. Such behavior impairs performance, development and improvement in these hospitals. Aim: Current study aimed to investigate the relationship between work place toxicity, organizational silence and thriving among nurses. Materials and method: A descriptive correlational research design was utilized with a  convenience  sample of 235 nurse were participated from different  departments at one of the general hospitals (El Salam Hospital) in Port Said, Egypt. Tools of data collection: Included staff nurses' personal characteristics, toxic workplace environment questionnaire, organizational silence scale, and thriving at work scale. Results: The lowest percent of staff nurses had high workplace toxicity and high level of organizational silence, meanwhile, more than half (53.6%) of them reflected passion for learning and wish to stay and headway in their hospital. A statistically significant negative correlation between thriving at work and workplace toxicity and organizational silence. A highly statistically significant positive correlation between toxic workplace environment and organizational silence was found. Conclusion: Work place toxicity contributes to more silence among staff nurses that prevent work flourishing and push nurses to leave. Recommendations: Continuous training programs for nurses to teach them about the importance of a healthy work environment to avoid the negative impacts of work place toxicity on psychological status.