Background: Mobile application is an innovative opportunity for pregnancy self-careand health literacy is crucial for primigravida's pregnancy self-care. Aim: This study aimed to examine the effect of mobile application intervention on health literacy regarding antenatal care among primigravida women during the COVID‑19 pandemic. In addition to assess the satisfaction level of primigravida toward mobile application utilization. Methods:  A quasi-experimental design (pretest/posttest for one group) was adopted. A purposive sample of 90 primigravida women was recruited and allocated to study group. The current study was conducted at outpatient antenatal clinic in Maternity hospital, Port Said Governorate, Egypt. Three tools were used for data collection: Structured interviewing questionnaire schedule, Maternal Health Literacy and Pregnancy (MHLAP) and satisfaction level tool. Results: There were highly statistically significant differences among  primigravida women on total score of health literacy regarding antenatal care and practice pre and post mobile application intervention . Fortunately, there were 86.7% of primigravida were satisfied toward mobile app utilization while only 13.3% of primigravida were dissatisfied. Conclusion: Mobile application intervention is effective on health literacy regarding antenatal care among primigravida women during the COVID ‑19 pandemic. Recommendation: Utilizing mobile application intervention on health literacy regarding antenatal care among pregnant women during the COVID ‑19 pandemic by nurses should be encouraged.