Abstract: Chemotherapy causes many acute side effects. Video games distraction is a method that helps in relieving adverse corollaries. Aim: To investigate the effect of video games on the adverse corollaries of chemotherapy at pediatric oncology patients. Design: A quasi-experimental research design was utilized. Subjects: - A convenient sample of 100 children suffering from cancer undergoing chemotherapy was equally assigned into two groups the video games group (50 children) and the control group (50 children). Setting: the study was applied at the pediatric department at the Oncology Institute at Sohag City and Sohag University Hospital. Tools: Two tools were used (1) demographic characteristics tool and (2) Rhodes Index of Nausea and Vomiting Likert scale. Results: Regarding items of Rhodes index of nausea &vomiting scale, it was found that all pediatric oncology patients (100%) in the video games group had no nausea compared to slightly more than three quarters in the control group. Conclusion: Pediatric oncology patients undergoing chemotherapy who received video games had experienced lower intensity of nausea and vomiting compared to children in the control group. Recommendations: Pediatric nurses should involve video game in routine care among pediatric oncology patients undergoing chemotherapy to reduce and manage side effects of chemotherapy.