Iron-deficiency anemia (IDA) considered one of the most common nutritional disorders which affected about 30 to 50 percent of children. Aim: To evaluate the effect of applying the PRECEDE model on controlling iron deficiency anemia among children. Subjects and method: Design: A quasi-experimental research design was utilized in this study. Settings: The study was applied in the Pediatric Outpatient Clinics at Sohag University Hospital and Maternal and Child Health Centers at Sohag City (Dar E Salam Abdallah health center). Sample: A convenient sample of 360 children and their mothers was recruited from the selected settings. Three tools were used: (1) Structured interviewing questionnaire, (2) (PRECEDE model questionnaire), and (3) investigation tool used to measure hemoglobin level. Results: knowledge, enabling factors, reinforcing factors, attitudes scores and behaviors of mothers about controlling IDA have been increased, and there was an increasing in the iron level of the studied children with statistical significance after three months of PRECEDE model application. Conclusion: It was concluded that PRECEDE Model application was very effective in improving knowledge and practice regarding IDA and modifying mothers' nutritional behaviors to control the IDA among their children. Recommendation: Dietary education is recommended for mothers during childhood to control and prevent IDA anemia.