Abstract: Multiple sclerosis is a complicated disease that has a major impact on quality of life. Self-management is necessary for carrying out active and emotional satisfaction of life to enable patients to be independent. Aim: To examine the effect of self-management program to adapt with multiple sclerosis problems and enhance quality of life. Design: A quasi-experimental design was utilized. Setting: The study was done at Multiple Sclerosis Outpatient Clinic, Ain Shams University Hospitals. Sample: A purposive sample includes 90 patients. Tools: A structured interview questionnaire was used, it include four parts: Patient''''s demographic characteristics, previous medical history and present health problems, patients knowledge, and Multiple sclerosis quality of life. Results: About two fifths of patients had poor knowledge pre program, this improved to nearly two thirds of them had good knowledge post selfmanagement program. About half of patients had low quality of life pre self-management program, this improved to one fifth of them had high quality of life post program. There was highly statistically significant correlation between total knowledge of patients and their quality of life pre and post self-management program (p value