Abstract Background: Immunoglobulin is an effective therapy in Guillain-Barre syndrome patients. Careful monitoring for side effects of immunoglobulin and reduction of complications remains mandatory for nursing care. Aim: To evaluate clinical outcomes post implementing nursing intervention for intravenous immunoglobulin recipient. Hypotheses: A significant reduction in complication incidence and length of hospital stay (ICU – department) among study group than control. Patients and Methods: Design: A quasi-experimental research design. Subjects: A convenience sample of sixty adult patients divided into study and control group diagnosed with Guillian Barre syndrome and had received intravenous immunoglobulin as a line of treatment. Setting: Neurological intensive care unit and department at Assiut University Hospital. Tools: I: patient assessment tool, II: four score assessment tool, and III: patient outcomes assessment tool. The control group subjected to routine hospital nursing intervention while study group received nursing intervention of IVIG administration. Results: Finding revealed a statistical significant decrease in disease complications, IVIG side effect, and hospital stay(ICU– department) in response to implemented nursing intervention between two groups p=0.003,0.004 respectively. Conclusion: Better clinical outcomes had been observed among intravenous immunoglobulin recipient with implemented nursing intervention Recommendation: Nursing intervention should be implement for all intravenous immunoglobulin recipient to achieve better clinical outcomes.