Abstract   Aim of The study to assess the mothers' knowledge about breast Feeding, bottle Feeding and weaning of their Infants. This study was carried out in all MCH centers at Minia city. Descriptive research design was used to meet the aim of study. A convenient sample included 1000 mothers who were attending MCH centers.A structured interview sheet was developed by the researcher based on review of relevant literature. It included 2 parts: Part I; included sociodemographic characteristics of the mother and child, Part II; included items related to mothers' knowledge about breast feeding, bottle feeding, and weaning. There were highly statistical significant differences between total knowledge of mother about breast feeding and all her socio-demographic characteristics. There was a positive relationship between maternal education and increased knowledge about infant feeding. Conclusion of this study illustrated that there is a relationship between knowledge of mother about breast feeding, bottle feeding ,and weaning and her socio-demographic characteristics and that there is a relationship between the education of mother with her knowledge about pattern of breast feeding, bottle feeding, and weaning and that there is a relationship between the occupation of mother and knowledge about exclusive breast feeding, duration of exclusive breast feeding. The study recommended that there is a dire need to arrange for health education program sessions for mothers with main emphasis on importance of colostrum's feeding, exclusive breast feeding & suitable age of starting and complete weaning.