Abstract: The descriptive study aimed at assessment nurses performance for patients with cancer receiving chemotherapy at South Egypt Cancer Institute at Assiut University: Subjects included in the study were 65 nurses from male, female and private oncology units. The collection of data was achieved by using observation checklist: this tool aims at assess performance of the nurses who providing care for patients with cancer receiving chemotherapy. It was developed by the researcher based on review of related literature. This tool consisted of two parts. Part I: Entailed. Socio-demographic characteristics of the studied nurses such as age, sex, qualification, and years of experience. Part II: Entailed the nursing care for patients with cancer receiving chemotherapy. It includes 147 criteria under 10 heading that identify nursing care for patient with cancer receiving chemotherapy. The results of the study showed that nursing care provided for patients with cancer receiving chemotherapy were inadequate. Based on the finding of the study. It is recommended that the oncology unit should be staffed with qualified and adequate nurses who are to make assessment and to provide adequate nursing intervention during three day shifts according to patients needs.