Abstract: Objective: are in need for different types of support the aim of this study to assess the physical, social, psychological, spiritual and educational needs of patients with obstructive sleep apnea and its associated ith morbidities. Patient and Methods: A descriptive exploratory study design was conducted at the Sleep center in Chest Department at Assiut University Hospital. Sample: A purposive sample of 100 adult patients from both sexes with OSA. Tools: a Patients' interviewing questionnaire sheet, Epworth Sleepiness Scales, Respiratory disturbed index (RDI) after full Polysomnographic study, patients' medical record, and Hamilton Rating Scale. Results: The study findings revealed that 30% of the studied patients were illiterate, 44% of them basic education and 26% of them were university and postgraduates. Moreover, 80% of them were overweight and obese the BMI < 25, 11% of them were smoker, added to them 68% of them had waist circumference < 102 in male and <88 in female. And 29% had neck size < 45cm in male and < 42cm in female. Nearly, 96% of them had respiratory, 95% nocturia and 79% digestive systems problems. Furthermore, 87% of the studied patients had tired and fatigued, 83% had day time sleepiness, 82% had obstruction breathing during sleep, 100% moderate and severe OSA and not present any mild case of OSA. Conclusion: There was no statistically significant relation between patients' needs and their characteristics, levels of sleepiness and depression. Statistical significant relation between physical, social, psychological and educational needs, level of OSA and educational needs with educational level. Furthermore, there was no statistically significant relation between patients' needs and age group, gender, and BMI.