Abstract Hospital readmissions are believed to be caused by patient frailty and progression of chronic disease. However, from 9% to 48% of all readmissions have been judged to be preventable because they were associated with indicators of substandard care during the index hospitalization, such as poor resolution of the main problem, unstable therapy at discharge, and inadequate post discharge care.Aim of the study is; intended to identify factors contributing to hospital readmission, and classify patient's group at high risk of readmission. Design of the study; was descriptive, retrospective and concurrent. Setting; thisstudy was carried out in Coronary Care Unit at Assuit University Hospital. The sample included 76 patients suffering mainly from cardiac disease. Tools used in this study consist of two parts; first closed chart audit; related to personal characteristics. Second, questionnaire about the reasons of hospital readmission; it included three aspects related to; the hospital, disease, and patients (post care interview). Results;of this study illustrated that most of readmitted patients were male, married, aged from 50 to 64 yearsold, most of them were read & write and had chronic illness and at the same time did not complied with medication and follow-up appointment. The study concluded that the present study demonstrates highly statistical significant differences between patient's related factors and frequency of readmission among studied patients, and highly statistical significant differences between Recommendation; based on the study findingthe following four strategies recommended reducing hospital readmission as following, screen for patients at risk for readmission, enhance the patient's education program, institute a telephone follow-up program after discharge, and emphasize the importance of data accuracy and integration.