Abstract Patient's undergoing abdominal Surgery often experience more severe postoperative discomfort than others. Aim of the study was to : Assess of patient's needs, Design nursing guideline, Evaluate the effect of application of designed nursing guideline on reducing post-operative discomfort among Patients Undergoing Abdominal Surgery. Research design: Quasi-experimental research design was utilized in this study. Patients and Method: the study was conducted in the Surgical department in Qena hospitals, Sample of (60) adult patient. Tools three tool were used: Tool I “Patients assessment questionnaire sheet", Tool II “designed nursing guidelines", Tool III The Symptoms Assessment Scale". Results showed that: majority of both the study and control group were female, married, illiterate, and unemployed. It was concluded that: the level of knowledge & practice of the study group patients after application of nursing guidelines was higher than control group patients. Most of the study group patients had minimal post-operative discomfort after application of nursing guidelines. It was recommended that Nurse Administrators can provide an in-service training on postoperative discomfort assessment and management to their staff. Also Nurses would be able to differentiate patients at the high risk of developing severe discomfort after abdominal surgery.