Khat chewing is a common habit among the population in the Jazan regions. Aim of the study: To identify the knowledge and attitude of nursing and non-nursing students as regard risks of chewing Khat and to perform a comparison between attitude and knowledge of nursing and non-nursing students as regard risks of chewing Khat. Study design and setting: Descriptive design was utilized on 323students in the Sabay University College at Jazan University Kingdom of Saudi Arabia. Method: Data were collected by using a self-administered questionnaire about knowledge, risks, and attitude of nursing and non-nursing students regarding risks of chewing Khat. Results: Shows that   about one-third of students are in (computer science, Accounting, and Nursing) departments with percentages (32.5%, 31.9 % and 35.6%) respectively.  And more than half (59.2%) of students in accounting study have a poor knowledge level and more than one-third (38.3 %) of nursing students have a poor knowledge as regarding risks of chewing Khat. Conclusion: The study found that nursing and non-nursing students had a poor knowledge level as well as a negative attitude toward khat chewing. Recommendations:   Implementing an educational program for students could  increase knowledge,  and awareness among university students and reduce the prevalence of the habit and its unfavorable consequences.