Context: Hysterectomy is the most common gynecologic surgical procedure among reproductive aged women in which complications with serious consequences may occur, thereby discharge planning for women undergoing hysterectomy is considered a strategy for promoting their health and wellbeing. Aim: The aim of this study was to assess the efficacy of implementing a discharge plan on women undergoing Hysterectomy. Methods: A Quasiexperimental (study/control group) design was utilized in this study. A purposive sample of 60 women recruited in this study that conducted at the Gynecological unit at Ain shames university maternity hospital. The study utilizes Four tools, I) Structured Interviewing Questionnaire, II) Structured self-care ability questionnaire III) Visual Analogue Scale (VAS), IIIV) in addition to follow up record and developed supportive material (discharge plan). Results: The present study revealed statistically significant differences between the study and control group regarding their total practice scores, mean pain score as well as health problems after hysterectomy pre, post, and follow up of intervention (P ≤ 0.001). Conclusions: The present study concluded that the implementation of a discharge plan has improved women's self-care practices post-hysterectomy in addition to a reduction in health problems and pain scores among studied women. The study Recommended: an updated discharge plan regarding self-care should be included in routine care for women undergoing hysterectomy. Also, further research is still needed to investigate the association between discharge plan and developing complications.