Abstract: Background: Patient with biliary stent should have life style modifications to help in minimizing post stent complications. Aim: Evaluate the effect of implementing nursing teaching protocol on health promotion life style for patients with plastic biliary stent. Research design: Quasi-experimental (Pre/test) research design. Setting: endoscopy unit at El-Rajhy hospital in Assuit University Hospital. sample: A convenience sample of 60 male and female adult patients Tools: (I), Patient assessment Tools: (II), Health promotion Model-instruments Results: A statistically significance difference between study and control pre and post three months of implementing nursing teaching protocol regarding health promotion life style with P. value 0.001. Conclusion: there was a great improvement in health promotion life style after implementation of nursing teaching protocol than pre. Recommendations: Simple instructions hand book should be available for patients about post-operative complications and patients health promotion life style of plastic biliary stent.