Abstract: Background: Numerous parents confront challenges to reply to their children' sexual issues. These issues are usually unexpected, but responding in a positive and proportional manner to them is the most difficult aspect of parenting. Aim: to explore the parents' attitude towards sex-education for their children. Design: Descriptive design was used in this study. Convenient sample of 545 parents were recruited for this study. Setting: Assiut University employees' work place. Tool: A structured interview questionnaire which includes 2 parts; 1- Personal data for both parents such as age, education, residence and number of their children. 2- Parents' attitude scale which was developed by the researchers to investigate parent' attitude toward sex education, it includes 29 statements with response of Yes/No. Results: There was positive attitude among more than three-quarters of participated parents, 58.5% of them reported that both mother and father are responsible for sex education. There are statistically significant relation between parents' talk about sex education, parents' sex, and mother education (P= 0.000, and 0.001). Conclusion & Recommendations: The majority of studied parents have positive attitudes towards sex-education to their children. Sex and age of parents, mother' education, and residency are factors which influences their attitudes. Conducting more research on trends towards sex education in a larger sample, and arrange obligatory training program and workshops for parents of 10 years or more children on their sex education.