Abstract Background: COVID-19 is a contagious beefily infectious respiratory disease; it's a public health emergency that performs varying degrees of respiratory, physical and psychological dysfunction. Aim of the study: to evaluate the effect of the rehabilitation program on dyspnea, physical activities and psychological wellbeing among patients with COVID19. Methods: quasi-experimental pretest-posttest study. The study was carried out in intensive care (ICU) and post COVID recovery unit at Qena Respiratory Hospital. A convenience sample of 50 adult patients from both sexes. The study tools; Tool 1: Self-reports Assessment Questionnaire. Tool 2: International Physical Activity Scale Tool 3: psychological symptoms scale. Tool 4: Clinical data base: includes laboratory investigation of lung function and ABGs, addition to chest tomography. Results: A significant statistically difference was found regarding symptoms associated total pain, pain intensity, dyspnea scores, physical activities, and psychological wellbeing of the studied sample between the pre and post assessment at the first week and second week post discharge and after the implementation of the rehabilitation program with p= 0.001. Conclusion: implementation of the rehabilitation program had statistically significant improvement in dyspnea scores, physical activities, anxiety, depression, pulmonary function, and laboratory investigations among patients with COVID 19. Recommendation: rehabilitation programs should be designed and implemented as individualized programs following a comprehensive evaluation.