Abstract Background: Patients with Hematological malignancy patient need extraordinary nursing precaution for improving the consequence and prevent post chemotherapy complication. Aim: To assess post chemotherapy complications among hematological malignancy patients. Methodology: Design: descriptive research design was utilized in this study. Setting: The study was conducted in intensive care unit at south Egypt cancer institute. Sample: A convenient sample of 60 patients with hematological Malignancy. Tools: Two tools used for data collection, (I): patient assessment tool consisted of patient Socio demographic, clinical data and Physical assessment. (II): Post chemotherapy complications assessment sheet. Results: main sex of the studied patients were male their ages were 24.4±5.04, more than one third of them diagnosed of AML. The main complications were, fever, malaise, fatigue, nausea, and mucositis. Also, the majority suffered from muscle cramps, bone pain, weakness and headache. Conclusion: The main complications were, fever, malise, fatigue, nausea, microsites, muscle cramps, bone pain, weakness and fatigue, headache and site reaction. Recommendation: Keep a standardized nursing guideline for assessing and caring of post chemotherapy complications among the hematological malignancy patients should be available in a written form in the oncology unit.