Abstract Background: Despite the application of artificial intelligence in healthcare continues to generate increasing interest, health sector employees still have mixed attitudes and perception regarding the implementation of artificial intelligence technologies. Aim: Investigate nurse managers' perspectives and attitudes toward using artificial intelligence technology in Health settings. Methods: Descriptive research design was used to achieve the study's aim on 130 nurse managers at Mansoura University Hospitals through a convenience sampling by using two questionnaires, Perception toward artificial intelligence questionnaire and General attitudes towards artificial intelligence questionnaire. Results: 84.6% of nurse managers had moderate perception towards using artificial intelligence in nursing settings. 65.4% of them had positive attitude toward using artificial intelligence in nursing settings. Conclusion: There is a highly significant positive correlation between nurse managers' perception and attitudes toward using artificial intelligence in health settings. Recommendations: Provide appropriate information about the benefits, challenges, and issues surrounding the implementation of artificial intelligence in nursing settings and the potentials of these technologies to improve health care processes and efficiencies. Encourage nurse managers to increase their knowledge toward artificial intelligence through workshop and training programs .Participation and support of hospital managers from the beginning of the implementation of the artificial intelligence system.