Vitiligo has more than a 3000year history, it affected quality of life and led to greater stigmatization of affected patients. Nowadays, in a more holistic view of management a decisive factor to understand the impact of diseases and improve the quality of nursing care. Researchers must be aware of how some diseases affect different aspects of patients' lives and how successful management may improve patients' quality of life Aim: Assess quality of life of patient with vitiligo Material & Methods: Design A descriptive design was used. Setting: Mina Elbasel dermatology hospital.Alexandria, Egypt. Subjects: A convenience sample of 100 patients Tools for data collection: Two tools were used for data collections Tool1: of patient with vitiligo assessment questionnaire, to determine sociodemographic characteristic, and clinical data, Tool 2:vitiligo life quality interview questionnaire to assess the quality of life in patient with vitiligo. Results: Majority of the studied patient sometimes had difficulty with sun exposure, had challenges at their school or work, felt uncomfortable when asked questions about their disease, felt embarrassment from vitiligo, issues with their partner, avoided physical contact with others or shared them, and they had family issues, felt isolated and had problems in their sexual relations. Also, there were a statistically significant correlation between quality of life for patients under study and their vitiligo in relation to their sex, occupation, level of education and marital status, disease duration and their family history.Conclusions:  Quality of life should be considered as one of the important outcome measures of management in patients with vitiligo. Recommendations:  Nurses should develop strategies to provide an effective educational program for patients with vitiligo 'to enhance their quality of life