Abstract Background: Total knee replacement is a surgical procedure in which the knee joint is replaced by prosthetic implant to replace the weight-bearing surfaces of the knee joint to relieve pain and disability. Aim of the study: To evaluate the effect of application of sports activities teaching protocol on total knee replacement patients outcomes. Method: Aquasi-experimental study design was utilized in this study. This study was conducted in the department of orthopedic surgery at Assiut University hospital. A total number (60) adult patient undergoing total knee replacement divided into study and control group. Tools: Demographic, medical data and knee outcome survey sports activities scale. Results: Revealed that there was a highly statistical significant difference between the patient in the study and control groups regarding the symptoms and function limitation affect , level of sport activity post protocol in (post procedure ,after three weeks,2,4and 6months with p ≤.001**. Conclusion: Patient's outcome was improved after application of sports activities protocol for patient with total knee replacement. Recommendation: Replication of the present study on a larger probability for generalization of the results.