Background Many patients with percutaneous balloon valvuloplasty had multiple complications. Thus, they need special nursing guidelines to reduce complications and improve outcomes needed for those patients. Aim of the study To evaluate the effectiveness of nursing guidelines on outcomes of patients with percutaneous balloon valvuloplasty. Research design A randomized control trial was utilized in this study. Settings The study was conducted in the cardiac catheterization unit at Al Orman University Hospital. Sample A convenience sample of 60 patients who were admitted to cardiac catheterization to receive percutaneous balloon valvuloplasty was divided into two equal groups; Intervention and control groups. Tool Ipatients' assessment sheet, it included four parts; socio-demographic data, patient's assessment measurements, laboratory investigations, and pain scale. Tool II: complications and patient outcome. Methods: the researchers assessed the hemodynamic parameters before and after the procedure. Results more than half (56.7%) of the study group had no large hematoma but most of the control group had < 5 cm of hematoma until discharge of percutaneous balloon valvuloplasty. There was a statistically significant difference between both groups regarding pain, hematoma, and bleeding. Conclusion: Nursing guidelines lead to significant improvement in the outcomes of patients with percutaneous balloon valvuloplasty. Recommendation Keep the nursing guideline of percutaneous balloon valvuloplasty available in the cardiac catheterization unit.