Abstract Background: Patellofemoral pain syndrome is characterized by anterior knee pain, which may limit the performance of functional daily activities. Aim: to evaluate the effect of physiotherapy integrated exercise rehabilitation protocol on outcomes of patients with patellofemoral pain syndrome Methods: Research design: A quasi - experimental (pre
/ post) design was used. Setting: The study was conducted in the Physiotherapy Department at Assiut University Hospital. Sample: A purposive sample of (60) adult patients aged 20- 65 years diagnosed with patellofemoral pain syndrome. Tools: two tools (I): Structured patient interview questionnaire; this tool consisted of two parts; Part 1: Patients demographic characteristics and Part 2: Patient's medical data assessment. Tool (II): Kujala Patellofemoral Questionnaire (KPQ) scale. Results: Exercise rehabilitation protocol resulted in a highly statistically significant difference in the pre / post protocol in the whole items of Kujala patellofemoral score. Conclusion: The exercise rehabilitation protocol was more effective in improving patient's outcomes (reducing pain, improving activities of daily living in patients with patellofemoral pain syndrome. Recommendation: Screening programs to identify the risk factors for prolonged pain and knee functional deficit, and the potential association with degenerative joint disease.