Background: The major challenge for a burn care team is nosocomial infection. Infection of the burn injury leading to septicemia is the main cause of death. Aims: Assess the relation between incidence and risk factors of septicemia among burned patients and design a suggested nursing educational brochure. Methods: A descriptive correlational research design was utilized, data were collected using; Tool (I) Structured interview questionnaire, consisted of patients' demographic and medical data, which included: general, local assessment, laboratory investigations, blood culture and patient prognosis. Tool (II) risk factors of septicemia. In addition to a suggested nursing educational brochure. Data collected for a full year (November 2017– October 2018) on (101) convenient burned patients admitted in the burn unit at Assiut University hospital. Results: The prevalence of septicemia, around one third of the studied burned patients had a positive blood culture (staphylococcus). The mean TBSA were 34.73±24.27, all patients had invasive devices, major of them had an abnormal CBC results and discharged but near one quarter dead. Conclusion: There were a statistically significant relation between cause of burn, TBSA, wound changes and dressing type with patient's positive blood culture results (septicemia). Recommendations: Application of the developing strategies for infection control, early detection and treatment of infection (septicemia) among the burned patients