The aim of the study was to identify risk factors for frequency of readmission among heart failure patients at Assiut University Hospital. Research design: A descriptive exploratory research design was utilized to conduct this study. Setting: This study was carried out in the cardiovascular medicine department at Assiut University Hospital. sample: The study sample consists of a (100) heart failure patients; ages ranged from 18-65 years old. Tools: Two tools were used; tool one: a patient assessment sheet, tool two: re-admission assessment sheet. Results: Frequency of patients' readmission in a period of (6) months was (31%), (64.5%) have readmitted once, (29.03%) twice and (6.45%) three times. Highest percent was readmitted within 60 days of discharge (38.7%), (19.4%) readmitted within 30 days of discharge and (19.4%) readmitted within 90 days of discharge. Drug non-compliance, diet poor compliance, uncontrolled diabetes mellitus, ischemia, anemia and worsening left ventricular function were the major risk factors for HF patients'readmission. Conclusion: Frequency of patients' readmission was (31%). Drug non-compliance, diet poor compliance, uncontrolled diabetes mellitus, ischemia, anemia and worsening left ventricular function were the major risk factors for HF patients 'readmission. Recommendations: Design educational programs for patients with HF to reduce frequency of readmission of those patients.