Background: Labor is a normal physiological process, which while should be an occasion for rejoicing, it also accompanies it with lots of pain, agony, and discomfort and certain risks. The aim of the study was to assess the effect of back massage and reflexology on labor pain reduction and vital signs during first stage of labor. Subjects and Methods: Quasi-experimental design was used to conduct this research .This study was carried out at obstetric emergency department at Sohag University Hospital. A purposive Sample of 150 women. Tools used in this study, Tool I: Patient assessment sheet. Tool II: Visual Analogue Scale. Tool III: Hemodynamic stability. The main results: showed that there are statistically significant differences regarding pain reduction before and after applying back massage and reflexology during first stage of labor and no statistically significant differences regarding vital signs before and after applying them . Conclusion: Both back massage and reflexology have effect on pain reduction and don't have effect on vital signs during first stage of labor. Recommendation: Further studies of efficacy as well as effectiveness are needed to determine the clinical applicability of back massage and reflexology in a large sample.