Background: scorpion stings represent an important and serious public health problem worldwide owing to their high incidence and potentially severe and often fatal clinical manifestations. Aim: Evaluate the effect of teaching program on nurse's performance about scorpion sting. Study design: Quasi experimental research design was utilized in this study. Setting: The study was conducted at Medical Emergency Unite in Assiut University. Sample all available nurses who were working at medical emergency unite. The sample size was (30) nurses. Tools: Two tools were used for data collection, Tool (1) Nurses' knowledge assessment sheet and Nurses' practices assessment tool. Method: preparatory, implementation and evaluation phases were used to implement study. Results: The total nurses' knowledge mean score improved from (9.23±2.69) pre educational program to (16.6±1.73) post its implementation, and total nurses' practice mean score improved from (81.13 ± 8) pre implementation of educational program to (110.13± 5.66) post its implementation. There was good improvement with highly significant difference (p < 0.001) related to knowledge and practice. Conclusion: Majority of nurses had a satisfactory level of knowledge and practice toward scorpion sting after applying educational program. Recommendation: Nurses need in-service training programs and refreshing courses to improve their knowledge and practice.