Vitiligo is a chronic disorder of the skin, characterized by progressive loss of melanocytes from the epidermis manifested as white macules or patches. This study aims to: Assess the effect of Nursing Guidelines on the life style pattern of patients with vitiligo. Research design: pre-post-test research design was utilized. Sample: this study included 40 adult patients with vitiligo their age between 18 to 60 years old and from both sexes. Setting: the study sample was recruited from the Dermatology Department, Assuit University Hospitals. Tools: three tools were used in this study: pre-post patient knowledge questionnaire sheet for healthy life style, and Pre-Post Patient Life Style Pattern Assessment Sheet for patients with vitiligo. Based on the result of the assessment phase nursing guidelines developed and implemented. Results: There was statistical significant difference between life style patterns pre-post the implementation of the nursing guidelines for patients with vitiligo. Conclusion: The study findings revealed that developing and implementing nursing guidelines based on the needs of patients with vitiligo were effective in improving their lifestyle.