Cardiogenic shock is a clinical syndrome characterized by end organ hypo perfusion. It's an irreversible condition may lead to cardiac arrest. Critical care nurses possess pivotal role in the assessment of patient with cardiac shock, providing treatment. Aim of the study: This study aimed to assess nurses' knowledge and practice regarding caring of patient with cardiogenic shock. Setting: the study was conducted in coronary care unit at Heart hospital Assiut University. Study design: A descriptive research design was utilized in the study. Subjects The study included 40 nurses working in the mentioned setting. Tools: two tools were used for data collection, Tool one: nurses' knowledge assessment tool. Tool two: observational checklist regarding caring of cardiogenic shock patients Results: revealed that total knowledge level of nurses were (72.5%) unsatisfactory level regarding care of cardiogenic shock patients and (27.5%) of nurses had a satisfactory level. While total nurses practice level were (82.5%) had an inadequate level regarding care for patient with cardiogenic shock and (17.5%) had an adequate level. Conclusion: Nurses showed inadequacy of their knowledge and practices regarding care of cardiogenic shock patients. Recommendations: The study recommends that an education program regarding care of cardiogenic shock patients be designed, conducted and monitored for nurses working in the ICU.