Introduction: Application and implementing standardized nursing care on patients with cardiogenic shock had a positive effect on critically patient outcomes, took a shorter time and is more economical. Aim: To evaluate the effect of implementing standardized nursing care on outcomes of patients with cardiogenic shock at the Coronary Care Unit. Design: Quasi-experimental research design. Setting: the study was conducted in the Coronary Care Unit at Assuit University Hospital. Sample: 60 critically ill patients were included in the study. They were categorized into two groups, study group who received standardized nursing care from both sex study and control group who received routine care (30 in each). Tools: Two tools developed by the researcher after reviewing the literature to assess the patient condition to form baseline data these tools were Tool I: patient demographic and medical data, tool II: patients outcomes assessment sheet. Results: the findings of the current study revealed there was a significant difference between study and control group regarding patients outcomes p.value<0.05. Conclusion: The application of standardized nursing care for a patient with cardiogenic shock had a statistically significant positive effect on their outcome. Recommendation: Application of standardized nursing care for the patient with cardiogenic shock in the Coronary Care Unit.