Aim of this study was to evaluate the effect of the designed education program on nurses' knowledge regarding immediate and long term management of patient with status asthmaticus. Design: A Qusi experimental research design was utilized in this study on a convenient sample of 30 nurses working at El -Mobara hospital. Data collection tools was; Nurse's Knowledge Questionnaire sheet, consisted from three parts part 1) demographic characteristics, part 2) knowledge assessment about status asthmaticus and part 3) assessment of immediate and long term management. In addition, designed education program. Results: The majority of them their age ranged from 20 -40 years. Majority of nurses had knowledge regarding care of patients with status asthmaticus at satisfactory level in post-test .while all of nurses had no knowledge regarding nursing care of bronchial asthma in pre-test. The study Concluded that application of designed education program for nurses about immediate and long term nursing management of patient with status asthmaticus was associated with significant improvements of nurses' knowledge. Therefore, the Researchers Recommended making a standardized written nursing care and training programs for nurses in asthmatic care to ensure high quality of information and care provided based on national and international standards.