Background: Venous thromboembolism (VTE) refers to a blood clot that starts in a vein. It includes both deep vein thrombosis and pulmonary embolism. Aim: Evaluate the effect of implementation of educational nursing protocol on minimizing VTE for patients undergoing simultaneously arthroscopic anterior cruciate ligament reconstruction (ACLR) and high tibial osteotomy (HTO). Research design: Quasi experimental (Pre/posttest) research design was utilized. Subjects: A convenient sample of 30 adult patients undergoing simultaneously arthroscopic ACLR and HTO (age: 18 to 50 years old) both sexes were recruited. Setting: The study was conducted in the Unit of Arthroscopy and Sports Injuries in Orthopedic Department and the Arthroscopic Outpatient Clinic at Assiut University Hospital. Tools: (I) Pre/post patient structured interview questionnaire and (II) VTE evaluation sheet. Result: there was statistical significant difference regarding total knowledge score for studied patients in pre and post implementing nursing protocol and no patients were developing VTE. Conclusion: the study findings revealed that educational nursing protocol were significally effective in improving patient's knowledge about VTE and in preventing VTE.