Background: Venous thromboembolism (VTE) a common complication and important cause of death. VTE consists of two forms: deep vein thrombosis (DVT) and pulmonary embolism (PE) venous thrombo embolism (VTE). Aim assess nurses' knowledge and practice about venous thrombo embolism for cancer surgery patients. Study design: A descriptive research design used in the study. Setting: The study was conducted in the surgical unit, at Aswan oncology center. Subjects: The study included on a convenience sample (30) nurses working in surgical unit, at Aswan oncology center. Tools: two tools were used for data collection, a structured Interview questionnaire sheet for nurses and an observation check list for nurses practice Result: The total score of Nurses' knowledge about VTE were unsatisfactory level (96.7%), also the total score of observed nurses' practice level regarding prevention was unsatisfactory (93.3%). Conclusion: Nurses` knowledge and practice levels regarding the care of Venous Thrombo Embolism for Cancer Surgery Patients and venous thromboembolism prevention were unsatisfactory which needed an improvement. Recommendation: Nurses needed for in-service training programs and increase awareness to update their knowledge and practice regarding the care of Venous Thrombo Embolism for Cancer Surgery Patients.