Background: Vulvovaginal candidiasis is the second commonest vaginal infection among women at reproductive age. Aim of the study was to assess the effect of nursing management of women suffering from vulvovaginal candidiasis by using cumin seed extract versus clotrimazole suppository. Subjects and methods: A randomized double-blind, controlled study design, conducted at gynecology clinic at Women's Health Hospital, Assuit University from May 2018 to July 2019. The Study was included 100 women divided into two groups study group (Cumin group) and control group (clotrimazole group) 50 in each group. Results: This study reveals that there was no statistical significant difference between cumin and clotrimazole groups regarding improving Symptoms of VVC after treatment (P>0.05) and there was highly statistically significant difference regarding women's personal hygienic practices before and after health education providing for women in both groups (P>0.001). Conclusion: Cumin seed extract vaginal suppository is as effective as clotrimazole vaginal suppository in treatment of VVC and health education play an important role in management of vaginal infection. Recommendations: More studies of large sample size are needed to confirm the effect of cumin seed extract in treatment of VVC in vivo. Improve awareness of women about proper personal hygienic practices.