Continuous positive air way pressure is a first line and gold standard for obstructive sleep apnea syndromes, the aim of this study was to evaluate the effect of nursing intervention on adaptation of patients with obstructive sleep apnea syndrome with continues positive air way presser. Patient and Methods: (Quiz experimental (pre and post test) research design was conducted at the Sleep center in Chest Department at Assiut University Hospital. Sample: A convenience sample of 100 adult patients from both sexes with obstructive sleep apnea syndromes and under treatment with continuous positive air way pressure. Data collection Tools: 3 tools were used including I: Patients' interviewing questionnaire sheet. II: STOP-BANG questionnaires. III: Respiratory disturbed index. Results: The study findings revealed that all of studied patients had obstructive sleep apnea syndromes, moderate or severe. All, of patients not know the benefit and effect of continuous positive air way pressure. But, after application of the nursing intervention the patient's level of knowledge about its important, using and caring of the machine by the patients improved. Conclusion: After the application of nursing intervention about the important of machine, the feeling of discomfort with the machine and mask are improved, number of normal sleeping hours increased with improvement of respiratory systems work.